State-dependent FRET reports calcium- and voltage-dependent gating-ring motions in BK channels

Large-conductance voltage- and calcium-dependent potassium channels (BK, “Big K+”) are important controllers of cell excitability. In the BK channel, a large C-terminal intracellular region containing a “gating-ring” structure has been proposed to transduce Ca(2+) binding into channel opening. Using...

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Main Authors: Miranda, Pablo, Contreras, Jorge E., Plested, Andrew J. R., Sigworth, Fred J., Holmgren, Miguel, Giraldez, Teresa
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612663/
https://ncbi.nlm.nih.gov/pubmed/23479636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1219611110
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