Anti-inflammatory role of PGD(2) in acute lung inflammation and therapeutic application of its signal enhancement

We investigated the role of prostaglandin D(2) (PGD(2)) signaling in acute lung injury (ALI), focusing on its producer–effector interaction in vivo. Administration of endotoxin increased edema and neutrophil infiltration in the WT mouse lung. Gene disruption of hematopoietic PGD synthase (H-PGDS) ag...

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Detalhes bibliográficos
Main Authors: Murata, Takahisa, Aritake, Kosuke, Tsubosaka, Yoshiki, Maruyama, Toshihiko, Nakagawa, Takayuki, Hori, Masatoshi, Hirai, Hiroyuki, Nakamura, Masataka, Narumiya, Shuh, Urade, Yoshihiro, Ozaki, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612619/
https://ncbi.nlm.nih.gov/pubmed/23479612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218091110
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