Anti-inflammatory role of PGD(2) in acute lung inflammation and therapeutic application of its signal enhancement

We investigated the role of prostaglandin D(2) (PGD(2)) signaling in acute lung injury (ALI), focusing on its producer–effector interaction in vivo. Administration of endotoxin increased edema and neutrophil infiltration in the WT mouse lung. Gene disruption of hematopoietic PGD synthase (H-PGDS) ag...

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Hauptverfasser: Murata, Takahisa, Aritake, Kosuke, Tsubosaka, Yoshiki, Maruyama, Toshihiko, Nakagawa, Takayuki, Hori, Masatoshi, Hirai, Hiroyuki, Nakamura, Masataka, Narumiya, Shuh, Urade, Yoshihiro, Ozaki, Hiroshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612619/
https://ncbi.nlm.nih.gov/pubmed/23479612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218091110
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