EP(2) and EP(4) receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals

Intestinal resident macrophages play an important role in gastrointestinal dysmotility by producing prostaglandins (PGs) and nitric oxide (NO) in inflammatory conditions. The causal correlation between PGs and NO in gastrointestinal inflammation has not been elucidated. In this study, we examined th...

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Autors principals: Tajima, Tsuyoshi, Murata, Takahisa, Aritake, Kosuke, Urade, Yoshihiro, Michishita, Masaki, Matsuoka, Toshiyuki, Narumiya, Shuh, Ozaki, Hiroshi, Hori, Masatoshi
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
Matèries:
Inflammation/Immunity/Mediators
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311437/
https://ncbi.nlm.nih.gov/pubmed/22159280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00264.2011
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