Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via α7nACh receptors on muscularis macrophages associated with postoperative ileus

BACKGROUND: The main symptom of postoperative ileus (POI) is an intestinal motility disorder in which monocytes/macrophages and neutrophils play crucial roles. Prokinetic 5-hydroxytryptamine 4 receptor (5-HT(4)R) agonists and dopamine receptor antagonists are potential therapeutic agents for directl...

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Autori principali: Tsuchida, Yasuaki, Hatao, Fumihiko, Fujisawa, Masahiko, Murata, Takahisa, Kaminishi, Michio, Seto, Yasuyuki, Hori, Masatoshi, Ozaki, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Group 2010
Soggetti:
Neurogastroenterology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071096/
https://ncbi.nlm.nih.gov/pubmed/21115544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2010.227546
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