Evaluation of Arsenic Trioxide by the Pediatric Preclinical Testing Program with a Focus on Ewing Sarcoma

Arsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 μM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC(50) value...

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Bibliographic Details
Main Authors: Smith, Malcolm A., Kang, Min H., Reynolds, C. Patrick, Kurmasheva, Raushan T., Alexander, Denise, Billups, Catherine A., Toretsky, Jeffrey A., Houghton, Peter J.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612422/
https://ncbi.nlm.nih.gov/pubmed/22315235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23391
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