Evaluation of Arsenic Trioxide by the Pediatric Preclinical Testing Program with a Focus on Ewing Sarcoma

Arsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 μM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC(50) value...

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Detalhes bibliográficos
Main Authors: Smith, Malcolm A., Kang, Min H., Reynolds, C. Patrick, Kurmasheva, Raushan T., Alexander, Denise, Billups, Catherine A., Toretsky, Jeffrey A., Houghton, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612422/
https://ncbi.nlm.nih.gov/pubmed/22315235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23391
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