Evaluation of Arsenic Trioxide by the Pediatric Preclinical Testing Program with a Focus on Ewing Sarcoma

Arsenic trioxide was tested against the PPTP in vitro panel (1.0 nM to 10 μM) and against the PPTP Ewing sarcoma in vivo panel administered intraperitoneally at a dose of 2.5 mg/kg daily × 5 per week for a planned treatment duration of 3 weeks. Arsenic trioxide showed a median relative IC(50) value...

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Hlavní autoři: Smith, Malcolm A., Kang, Min H., Reynolds, C. Patrick, Kurmasheva, Raushan T., Alexander, Denise, Billups, Catherine A., Toretsky, Jeffrey A., Houghton, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612422/
https://ncbi.nlm.nih.gov/pubmed/22315235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.23391
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