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Brain regional correlation of amyloid-β with synapses and apolipoprotein E in non-demented individuals: potential mechanisms underlying regional vulnerability to amyloid-β accumulation

To reveal the underlying mechanisms responsible for the regional vulnerability to amyloid-β (Aβ) accumulation prior to the development of Alzheimer’s disease, we studied distribution of Aβ, apolipoprotein E (apoE), synaptic markers, and other molecules involved in Aβ metabolism in multiple brain are...

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Detalhes bibliográficos
Main Authors: Shinohara, Mitsuru, Petersen, Ronald C., Dickson, Dennis W., Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3612369/
https://ncbi.nlm.nih.gov/pubmed/23371365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-013-1086-9
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