Inhibition of replicon initiation in human cells following stabilization of topoisomerase-DNA cleavable complexes.

Diploid human fibroblast strains were treated for 10 min with inhibitors of type I and type II DNA topoisomerases, and after removal of the inhibitors, the rate of initiation of DNA synthesis at replicon origins was determined. By alkaline elution chromatography, 4'-(9-acridinylamino)methanesul...

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Bibliografiska uppgifter
Huvudupphovsmän: Kaufmann, W K, Boyer, J C, Estabrooks, L L, Wilson, S J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1991
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC361136/
https://ncbi.nlm.nih.gov/pubmed/1646393
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