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Processing of topoisomerase I cleavable complexes into DNA damage by transcription.

Topoisomerase I (TOP1)-mediated DNA damage induced by camptothecin (CPT) in the presence of active transcription has been studied using purified calf thymus TOP1 and T7 RNA polymerase. CPT-stabilized TOP1 cleavable complexes located on the template strand within the transcribed region were found to...

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Detalhes bibliográficos
Main Authors: Wu, J, Liu, L F
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC147056/
https://ncbi.nlm.nih.gov/pubmed/9336444
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