The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases

Histone deacetylases 4 (HDAC4), -5, -7, and -9 form class IIa within the HDAC superfamily and regulate diverse physiological and pathological cellular programs. With conserved motifs for phosphorylation-dependent 14-3-3 binding, these deacetylases serve as novel signal transducers that are able to m...

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Hlavní autoři: Walkinshaw, Donald R., Weist, Ryan, Kim, Go-Woon, You, Linya, Xiao, Lin, Nie, Jianyun, Li, Cathy S., Zhao, Songping, Xu, Minghong, Yang, Xiang-Jiao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3611005/
https://ncbi.nlm.nih.gov/pubmed/23393134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.456996
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