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Protein Kinase Cζ-dependent LKB1 Serine 428 Phosphorylation Increases LKB1 Nucleus Export and Apoptosis in Endothelial Cells

LKB1 is a serine-threonine protein kinase that, when inhibited, may result in unregulated cell growth and tumor formation. However, how LKB1 is regulated remains poorly understood. The aim of the present study was to define the upstream signaling events responsible for peroxynitrite (ONOO(-))-induce...

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Main Authors: Song, Ping, Xie, Zhonglin, Wu, Yong, Xu, Jian, Dong, Yunzhou, Zou, Ming-Hui
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431011/
https://ncbi.nlm.nih.gov/pubmed/18321849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708208200
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