Stimulation of Autophagy Improves Endoplasmic Reticulum Stress–Induced Diabetes

Accumulation of misfolded proinsulin in the β-cell leads to dysfunction induced by endoplasmic reticulum (ER) stress, with diabetes as a consequence. Autophagy helps cellular adaptation to stress via clearance of misfolded proteins and damaged organelles. We studied the effects of proinsulin misfold...

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Главные авторы: Bachar-Wikstrom, Etty, Wikstrom, Jakob D., Ariav, Yafa, Tirosh, Boaz, Kaiser, Nurit, Cerasi, Erol, Leibowitz, Gil
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2013
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609555/
https://ncbi.nlm.nih.gov/pubmed/23274896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1474
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