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Single-molecule approaches to prion protein misfolding

The structural conversion of the prion protein PrP into a transmissible, misfolded form is the central element of prion disease, yet there is little consensus as to how it occurs. Key aspects of conversion into the diseased state remain unsettled, from details about the earliest stages of misfolding...

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Autors principals: Yu, Hao, Dee, Derek R., Woodside, Michael T.
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609121/
https://ncbi.nlm.nih.gov/pubmed/23357831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.23303
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