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Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice
Prion diseases are caused by a conformational modification of the cellular prion protein (PrP(C)) into disease-specific forms, termed PrP(Sc), that have the ability to interact with PrP(C) promoting its conversion to PrP(Sc). In vitro studies demonstrated that anti-PrP antibodies inhibit this proces...
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| Główni autorzy: | , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Landes Bioscience
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609068/ https://ncbi.nlm.nih.gov/pubmed/22842862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.20197 |
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