Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice

Prion diseases are caused by a conformational modification of the cellular prion protein (PrP(C)) into disease-specific forms, termed PrP(Sc), that have the ability to interact with PrP(C) promoting its conversion to PrP(Sc). In vitro studies demonstrated that anti-PrP antibodies inhibit this proces...

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Detalhes bibliográficos
Main Authors: Moda, Fabio, Vimercati, Chiara, Campagnani, Ilaria, Ruggerone, Margherita, Giaccone, Giorgio, Morbin, Michela, Zentilin, Lorena, Giacca, Mauro, Zucca, Ileana, Legname, Giuseppe, Tagliavini, Fabrizio
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3609068/
https://ncbi.nlm.nih.gov/pubmed/22842862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.20197
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