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What’s to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?
α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3609056/ https://ncbi.nlm.nih.gov/pubmed/23360753 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.23806 |
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