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Prying into the Prion Hypothesis for Parkinson's Disease

In Parkinson's disease, intracellular α-synuclein inclusions form in neurons. We suggest that prion-like behavior of α-synuclein is a key component in Parkinson's disease pathogenesis. Although multiple molecular changes are involved in the triggering of the disease process, we propose tha...

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Detalles Bibliográficos
Publicado en:J Neurosci
Autores principales: Brundin, Patrik, Melki, Ronald
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5637113/
https://ncbi.nlm.nih.gov/pubmed/29021298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1788-16.2017
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