BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state

BACKGROUND: Chronic pain is an important medical problem affecting hundreds of millions of people worldwide. Mechanisms underlying the maintenance of chronic pain states are poorly understood but the elucidation of such mechanisms have the potential to reveal novel therapeutics capable of reversing...

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Main Authors: Melemedjian, Ohannes K, Tillu, Dipti V, Asiedu, Marina N, Mandell, Edward K, Moy, Jamie K, Blute, Victoria M, Taylor, Caleb J, Ghosh, Sourav, Price, Theodore J
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608966/
https://ncbi.nlm.nih.gov/pubmed/23510079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-9-12
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