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Global Conformational Selection and Local Induced Fit for the Recognition between Intrinsic Disordered p53 and CBP
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription. NMR experiments demonstrate that both apo-NCBD and TAD are intrinsic disordered and bound NCBD/TAD und...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608666/ https://ncbi.nlm.nih.gov/pubmed/23555731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059627 |
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