Global Conformational Selection and Local Induced Fit for the Recognition between Intrinsic Disordered p53 and CBP

The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription. NMR experiments demonstrate that both apo-NCBD and TAD are intrinsic disordered and bound NCBD/TAD und...

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Detaylı Bibliyografya
Asıl Yazarlar: Yu, Qingfen, Ye, Wei, Wang, Wei, Chen, Hai-Feng
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608666/
https://ncbi.nlm.nih.gov/pubmed/23555731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059627
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