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Global Conformational Selection and Local Induced Fit for the Recognition between Intrinsic Disordered p53 and CBP

The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription. NMR experiments demonstrate that both apo-NCBD and TAD are intrinsic disordered and bound NCBD/TAD und...

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Detalhes bibliográficos
Main Authors: Yu, Qingfen, Ye, Wei, Wang, Wei, Chen, Hai-Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608666/
https://ncbi.nlm.nih.gov/pubmed/23555731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059627
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