A Systematic In Silico Search for Target Similarity Identifies Several Approved Drugs with Potential Activity against the Plasmodium falciparum Apicoplast

Most of the drugs in use against Plasmodium falciparum share similar modes of action and, consequently, there is a need to identify alternative potential drug targets. Here, we focus on the apicoplast, a malarial plastid-like organelle of algal source which evolved through secondary endosymbiosis. W...

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Bibliografske podrobnosti
Main Authors: Bispo, Nadlla Alves, Culleton, Richard, Silva, Lourival Almeida, Cravo, Pedro
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608639/
https://ncbi.nlm.nih.gov/pubmed/23555651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059288
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