Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets

Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible for 90% of all the cases. Recent reports on artemisinin resistance in Southeast Asia warrant urgent discovery of novel drugs for the treatment of malaria. However, most bioactive compounds fail to progr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Mogire, Reagan M., Akala, Hoseah M., Macharia, Rosaline W., Juma, Dennis W., Cheruiyot, Agnes C., Andagalu, Ben, Brown, Mathew L., El-Shemy, Hany A., Nyanjom, Steven G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663372/
https://ncbi.nlm.nih.gov/pubmed/29088219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186364
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