Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets

Malaria causes about half a million deaths annually, with Plasmodium falciparum being responsible for 90% of all the cases. Recent reports on artemisinin resistance in Southeast Asia warrant urgent discovery of novel drugs for the treatment of malaria. However, most bioactive compounds fail to progr...

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Udgivet i:PLoS One
Main Authors: Mogire, Reagan M., Akala, Hoseah M., Macharia, Rosaline W., Juma, Dennis W., Cheruiyot, Agnes C., Andagalu, Ben, Brown, Mathew L., El-Shemy, Hany A., Nyanjom, Steven G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5663372/
https://ncbi.nlm.nih.gov/pubmed/29088219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186364
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