A Systematic In Silico Search for Target Similarity Identifies Several Approved Drugs with Potential Activity against the Plasmodium falciparum Apicoplast

Most of the drugs in use against Plasmodium falciparum share similar modes of action and, consequently, there is a need to identify alternative potential drug targets. Here, we focus on the apicoplast, a malarial plastid-like organelle of algal source which evolved through secondary endosymbiosis. W...

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Главные авторы: Bispo, Nadlla Alves, Culleton, Richard, Silva, Lourival Almeida, Cravo, Pedro
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608639/
https://ncbi.nlm.nih.gov/pubmed/23555651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059288
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