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Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6
The long-acting opioid methadone displays considerable unexplained interindividual pharmacokinetic variability. Methadone metabolism clinically occurs primarily by N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), catalyzed predominantly by CYP2B6. Retrospective studies suggest...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608451/ https://ncbi.nlm.nih.gov/pubmed/23298862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.050625 |
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