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The Mechanism of Autoinduction of Methadone N-demethylation in Human Hepatocytes
BACKGROUND: There is considerable inter-and intraindividual variability in methadone metabolism and clearance. Methadone dosing is particularly challenging during initiation of therapy, due to time-dependent increases in hepatic clearance (autoinduction). Although methadone N-demethylation is cataly...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3870592/ https://ncbi.nlm.nih.gov/pubmed/23733841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0b013e3182918252 |
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