Bayesian Models Leveraging Bioactivity and Cytotoxicity Information for Drug Discovery

Identification of unique leads represents a significant challenge in drug discovery. This hurdle is magnified in neglected diseases such as tuberculosis. We have leveraged public high-throughput screening (HTS) data, to experimentally validate virtual screening approach employing Bayesian models bui...

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Hlavní autoři: Ekins, Sean, Reynolds, Robert C., Kim, Hiyun, Koo, Mi-Sun, Ekonomidis, Marilyn, Talaue, Meliza, Paget, Steve D., Woolhiser, Lisa K., Lenaerts, Anne J., Bunin, Barry A., Connell, Nancy, Freundlich, Joel S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607962/
https://ncbi.nlm.nih.gov/pubmed/23521795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.01.011
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