Silica induces NLRP3 inflammasome activation in human lung epithelial cells

BACKGROUND: In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. I...

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Hlavní autoři: Peeters, Paul M, Perkins, Timothy N, Wouters, Emiel F M, Mossman, Brooke T, Reynaert, Niki L
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607900/
https://ncbi.nlm.nih.gov/pubmed/23402370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-8977-10-3
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