Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

RATIONALE: Mineral particles in the lung cause inflammation and silicosis. In myeloid and bronchial epithelial cells the inflammasome plays a role in responses to crystalline silica. Thioredoxin (TRX) and its inhibitory protein TRX-interacting protein link oxidative stress with inflammasome activati...

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Detalhes bibliográficos
Publicado no:Part Fibre Toxicol
Main Authors: Peeters, Paul M, Eurlings, Irene M J, Perkins, Timothy N, Wouters, Emiel F, Schins, Roel P F, Borm, Paul J A, Drommer, Wolfgang, Reynaert, Niki L, Albrecht, Catrin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4243278/
https://ncbi.nlm.nih.gov/pubmed/25406505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12989-014-0058-0
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