WIP1 Enhances Tumor Formation in a Sonic Hedgehog–Dependent Model of Medulloblastoma

BACKGROUND: A significant number of medulloblastomas (MBs) originate from abnormal activation of the sonic hedgehog/patched (SHH/PTC) signaling pathway. Although p53 deficiency enhances tumor formation in mice, inactivation of the p53 gene is seen in a minority of MBs. Wild-type p53-induced phosphat...

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Главные авторы: Doucette, Tiffany A., Yang, Yuhui, Pedone, Carolyn, Kim, John Y.H., Dubuc, Adrian, Northcott, Paul D., Taylor, Michael D., Fults, Daniel W., Rao, Ganesh
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607499/
https://ncbi.nlm.nih.gov/pubmed/22037313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0b013e31823e5332
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