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WIP1 Enhances Tumor Formation in a Sonic Hedgehog–Dependent Model of Medulloblastoma
BACKGROUND: A significant number of medulloblastomas (MBs) originate from abnormal activation of the sonic hedgehog/patched (SHH/PTC) signaling pathway. Although p53 deficiency enhances tumor formation in mice, inactivation of the p53 gene is seen in a minority of MBs. Wild-type p53-induced phosphat...
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| Hlavní autoři: | , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607499/ https://ncbi.nlm.nih.gov/pubmed/22037313 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0b013e31823e5332 |
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