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Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression

Parkinson's disease (PD) is the second most common neurodegenerative disorder in the developed world, and is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN). Somatic mitochondrial DNA (mtDNA) deletions reach their highest concentration with age in the SN in h...

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Detalhes bibliográficos
Main Authors: Song, Lanying, Shan, Yuxi, Lloyd, K.C. Kent, Cortopassi, Gino A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607469/
https://ncbi.nlm.nih.gov/pubmed/22949510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds365
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