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RANKL employs distinct binding modes to engage RANK and the OPG decoy receptor

Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B (RANK) are members of the TNFR superfamily that regulate osteoclast formation and function by competing for RANK ligand (RANKL). RANKL promotes osteoclast development through RANK activation, while OPG inhibits this process by se...

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Bibliografische gegevens
Hoofdauteurs: Nelson, Christopher A., Warren, Julia T., Wang, Michael W.H., Teitelbaum, Steven L., Fremont, Daved H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607351/
https://ncbi.nlm.nih.gov/pubmed/23039992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.030
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