RANKL employs distinct binding modes to engage RANK and the OPG decoy receptor

Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B (RANK) are members of the TNFR superfamily that regulate osteoclast formation and function by competing for RANK ligand (RANKL). RANKL promotes osteoclast development through RANK activation, while OPG inhibits this process by se...

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Autors principals: Nelson, Christopher A., Warren, Julia T., Wang, Michael W.H., Teitelbaum, Steven L., Fremont, Daved H.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607351/
https://ncbi.nlm.nih.gov/pubmed/23039992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.030
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