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RANKL employs distinct binding modes to engage RANK and the OPG decoy receptor
Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B (RANK) are members of the TNFR superfamily that regulate osteoclast formation and function by competing for RANK ligand (RANKL). RANKL promotes osteoclast development through RANK activation, while OPG inhibits this process by se...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3607351/ https://ncbi.nlm.nih.gov/pubmed/23039992 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.030 |
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