Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imaging

BACKGROUND: The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)–mediated flux from pyruvate to acetyl c...

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Bibliographic Details
Main Authors: Park, Jae Mo, Recht, Lawrence D., Josan, Sonal, Merchant, Milton, Jang, Taichang, Yen, Yi-Fen, Hurd, Ralph E., Spielman, Daniel M., Mayer, Dirk
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Basic and Translational Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607261/
https://ncbi.nlm.nih.gov/pubmed/23328814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos319
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