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L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors

Epigenetic mechanisms are involved in the pathophysiology of depressive disorders and are unique potential targets for therapeutic intervention. The acetylating agent L-acetylcarnitine (LAC), a well-tolerated drug, behaves as an antidepressant by the epigenetic regulation of type 2 metabotropic glut...

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Detalhes bibliográficos
Main Authors: Nasca, Carla, Xenos, Dionysios, Barone, Ylenia, Caruso, Alessandra, Scaccianoce, Sergio, Matrisciano, Francesco, Battaglia, Giuseppe, Mathé, Aleksander A., Pittaluga, Anna, Lionetto, Luana, Simmaco, Maurizio, Nicoletti, Ferdinando
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607061/
https://ncbi.nlm.nih.gov/pubmed/23382250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216100110
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