Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum’s functions. Host DNA rapidly coats injected alum. Here, we further investigated the mechanism of alum and DNA’s adjuvant function. Our data show that DNase coinjection reduces CD4 T-cell priming by i.m. inject...

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Bibliografiska uppgifter
Huvudupphovsmän: McKee, Amy S., Burchill, Matthew A., Munks, Michael W., Jin, Lei, Kappler, John W., Friedman, Rachel S., Jacobelli, Jordan, Marrack, Philippa
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2013
Ämnen:
PNAS Plus
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607057/
https://ncbi.nlm.nih.gov/pubmed/23447566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300392110
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