Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum’s functions. Host DNA rapidly coats injected alum. Here, we further investigated the mechanism of alum and DNA’s adjuvant function. Our data show that DNase coinjection reduces CD4 T-cell priming by i.m. inject...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McKee, Amy S., Burchill, Matthew A., Munks, Michael W., Jin, Lei, Kappler, John W., Friedman, Rachel S., Jacobelli, Jordan, Marrack, Philippa
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607057/
https://ncbi.nlm.nih.gov/pubmed/23447566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300392110
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