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Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

Many vaccines include aluminum salts (alum) as adjuvants despite little knowledge of alum’s functions. Host DNA rapidly coats injected alum. Here, we further investigated the mechanism of alum and DNA’s adjuvant function. Our data show that DNase coinjection reduces CD4 T-cell priming by i.m. inject...

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Autores principales: McKee, Amy S., Burchill, Matthew A., Munks, Michael W., Jin, Lei, Kappler, John W., Friedman, Rachel S., Jacobelli, Jordan, Marrack, Philippa
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607057/
https://ncbi.nlm.nih.gov/pubmed/23447566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300392110
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