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Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

Vaccines can greatly reduce the spread of and deaths from many infectious diseases. However, many infections have no successful vaccines. Better understanding of the generation of protective CD8 memory T cells by vaccination is essential for the rational design of new vaccines that aim to prime cell...

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Autori principali: MacLeod, Megan K. L., McKee, Amy S., David, Alexandria, Wang, Jieru, Mason, Robert, Kappler, John W., Marrack, Philippa
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3093483/
https://ncbi.nlm.nih.gov/pubmed/21518876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104588108
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