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Gr1+ IL-4 producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses.
Alum is used as a vaccine adjuvant and induces Th2 responses and Th2-driven antibody isotype production against co-injected antigens. Alum also promotes the appearance in the spleen of Gr1+, IL-4+ innate cells that, via IL-4 production, induce MHC II mediated signaling in B cells. To investigate whe...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2935467/ https://ncbi.nlm.nih.gov/pubmed/18343889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn025 |
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