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Gr1+ IL-4 producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses.

Alum is used as a vaccine adjuvant and induces Th2 responses and Th2-driven antibody isotype production against co-injected antigens. Alum also promotes the appearance in the spleen of Gr1+, IL-4+ innate cells that, via IL-4 production, induce MHC II mediated signaling in B cells. To investigate whe...

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Главные авторы: McKee, Amy, MacLeod, Megan, White, Janice, Crawford, Frances, Kappler, John, Marrack, Philippa
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935467/
https://ncbi.nlm.nih.gov/pubmed/18343889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxn025
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