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Crucial role of the hydrophobic pocket region of Munc18 protein in mast cell degranulation

The function of the Munc18-1 protein hydrophobic pocket, which interacts with the syntaxin-1 N-terminal peptide, has been highly controversial in neurosecretion. Recent analysis of patients with familial hemophagocytic lymphohistiocytosis type 5 has identified the E132A mutation in the hydrophobic p...

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Hlavní autoři: Bin, Na-Ryum, Jung, Chang Hun, Piggott, Christopher, Sugita, Shuzo
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607013/
https://ncbi.nlm.nih.gov/pubmed/23487749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214887110
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