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From mechanical folding trajectories to intrinsic energy landscapes of biopolymers

In single-molecule laser optical tweezer (LOT) pulling experiments, a protein or RNA is juxtaposed between DNA handles that are attached to beads in optical traps. The LOT generates folding trajectories under force in terms of time-dependent changes in the distance between the beads. How to construc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Hinczewski, Michael, Gebhardt, J. Christof M., Rief, Matthias, Thirumalai, D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606983/
https://ncbi.nlm.nih.gov/pubmed/23487746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214051110
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