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Reconstructing folding energy landscapes from splitting probability analysis of single-molecule trajectories

Structural self-assembly in biopolymers, such as proteins and nucleic acids, involves a diffusive search for the minimum-energy state in a conformational free-energy landscape. The likelihood of folding proceeding to completion, as a function of the reaction coordinate used to monitor the transition...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Manuel, Ajay P., Lambert, John, Woodside, Michael T.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466695/
https://ncbi.nlm.nih.gov/pubmed/26039984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419490112
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