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Real-time control of the energy landscape by force directs the folding of RNA molecules

The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: indivi...

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Detalhes bibliográficos
Main Authors: Li, Pan T. X., Bustamante, Carlos, Tinoco, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855384/
https://ncbi.nlm.nih.gov/pubmed/17438300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702137104
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