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Real-time control of the energy landscape by force directs the folding of RNA molecules
The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: indivi...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1855384/ https://ncbi.nlm.nih.gov/pubmed/17438300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702137104 |
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