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Real-time control of the energy landscape by force directs the folding of RNA molecules

The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: indivi...

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Bibliografische gegevens
Hoofdauteurs: Li, Pan T. X., Bustamante, Carlos, Tinoco, Ignacio
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1855384/
https://ncbi.nlm.nih.gov/pubmed/17438300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702137104
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