Chromosomal destabilization during gene amplification.

Acentric extrachromosomal elements, such as submicroscopic autonomously replicating circular molecules (episomes) and double minute chromosomes, are common early, and in some cases initial, intermediates of gene amplification in many drug-resistant and tumor cell lines. In order to gain a more compl...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Ruiz, J C, Wahl, G M
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2188107/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.3056-3066.1990
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