Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive interstitial lung disease, wherein transforming growth factor β (TGF-β) and sphingosine-1-phosphate (S1P) contribute to the pathogenesis of fibrosis. However, the in vivo contribution of sphingosine kinase (SphK) in fibrotic processes...

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Hauptverfasser: Huang, Long Shuang, Berdyshev, Evgeny, Mathew, Biji, Fu, Panfeng, Gorshkova, Irina A., He, Donghong, Ma, Wenli, Noth, Imre, Ma, Shwu-Fan, Pendyala, Srikanth, Reddy, Sekhar P., Zhou, Tong, Zhang, Wei, Garzon, Steven A., Garcia, Joe G. N., Natarajan, Viswanathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2013
Schlagworte:
Research Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3606540/
https://ncbi.nlm.nih.gov/pubmed/23315259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-219634
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