Inhibition of topoisomerase II does not inhibit transcription of RNA polymerase I and II genes.
Injection of VM-26 (teniposide) into Xenopus oocytes inhibits the activity of topoisomerase II but does not inhibit transcription by RNA polymerases I and II. A specific assay for topoisomerase II, resolution of catenated DNA molecules into product rings, was used to quantitate VM-26 inhibition in v...
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| Udgivet i: | Mol Cell Biol |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
1990
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC360651/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2160588/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.10.6.2893-2900.1990 |
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