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Inhibition of topoisomerase II does not inhibit transcription of RNA polymerase I and II genes.

Injection of VM-26 (teniposide) into Xenopus oocytes inhibits the activity of topoisomerase II but does not inhibit transcription by RNA polymerases I and II. A specific assay for topoisomerase II, resolution of catenated DNA molecules into product rings, was used to quantitate VM-26 inhibition in v...

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Detalhes bibliográficos
Autor principal: Dunaway, M
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC360651/
https://ncbi.nlm.nih.gov/pubmed/2160588
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